<p>Now unit contains</p>
<pre><code>RuntimeDirectory=kamailio
</code></pre>
<p>According docs</p>
<blockquote>
<p>The specified directory names must be relative, and may not include "..". If set, one or more directories by the specified names will be created (including their parents) below the locations defined in the following table, when the unit is started.</p>
</blockquote>
<p>According table base patch  for relative directory is <code>/run</code> (<code>Below path for system units</code> column).</p>
<p>Look as current definition correct</p>

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